Because of gluten activated immune system contributes to development of fatal cancer of the blood
A small group of adult patients with gluten intolerance (celiac disease) is developing an aggressive form of white blood cell cancer. Researchers at the Leiden University Medical Center (LUMC) have now shown that allow the gluten immune system cells produce substances that can contribute significantly to the occurrence of this cancer type. Research leader Dr Jeroen van Bergen:. "The immune system is widely seen as an ally in the fight against cancer, but apparently is not always on."
resistant celiac disease
TarweEr are people who get severe chronic inflammation after eating cereal as wheat, barley and rye in the small intestine. Evildoers are certain proteins called gluten. Cells of the immune system react violently to this extraordinary gluten. The medical term for this (genetic) gluten intolerance is celiac disease. CD patients keep the symptoms generally good in the hand with a gluten-free diet. A small percentage (2-5%) of patients with celiac disease is established in adulthood, however, does not respond to such a diet: there is resistant celiac disease. In a particular form thereof show patients show an unrestrained proliferation of immature white blood cells (lymphocytes) that are located in the wall of the small intestine. In about half of these patients they develop into a malignant, incurable form of white blood cell cancer (lymphoma).
growth factors
It has long been known that these cancer cells for their survival and multiplication are dependent on a growth stimulating protein. But now researchers at the LUMC (department Immune Haematology and Blood Transfusion, Department of Pediatrics and Center for Proteomics and Metabolomics) and VUMC demonstrated (Department of Gastroenterology & Hepatology) the propagation of lymphoma cells can be encouraged just as strongly by three other growth factors, which are made by the immune cells which specifically recognize the said gluten. The immune system itself appears to contribute significantly to the development of this aggressive blood cancer.
Targeted drugs
An important question is really important growth factors which stage of development to lymphoma. Bergen: "It is likely that at the time of diagnosis already has decades of slumbering colitis patients. To what extent it helps to prevent the effect of the newly discovered growth factors with targeted drugs? Meanwhile, we have tested a large number of these substances in the laboratory and two seem promising. But that is therapeutically only interesting if these growth factors are also after the diagnosis still play a significant role. "
The findings of the Leiden and Amsterdam researchers published on January 3 in the journal Proceedings of the National Academy of Sciences of the USA (PNAS USA). The research was supported by a grant from Cancer Research Worldwide (WWCR).
resistant celiac disease
TarweEr are people who get severe chronic inflammation after eating cereal as wheat, barley and rye in the small intestine. Evildoers are certain proteins called gluten. Cells of the immune system react violently to this extraordinary gluten. The medical term for this (genetic) gluten intolerance is celiac disease. CD patients keep the symptoms generally good in the hand with a gluten-free diet. A small percentage (2-5%) of patients with celiac disease is established in adulthood, however, does not respond to such a diet: there is resistant celiac disease. In a particular form thereof show patients show an unrestrained proliferation of immature white blood cells (lymphocytes) that are located in the wall of the small intestine. In about half of these patients they develop into a malignant, incurable form of white blood cell cancer (lymphoma).
growth factors
It has long been known that these cancer cells for their survival and multiplication are dependent on a growth stimulating protein. But now researchers at the LUMC (department Immune Haematology and Blood Transfusion, Department of Pediatrics and Center for Proteomics and Metabolomics) and VUMC demonstrated (Department of Gastroenterology & Hepatology) the propagation of lymphoma cells can be encouraged just as strongly by three other growth factors, which are made by the immune cells which specifically recognize the said gluten. The immune system itself appears to contribute significantly to the development of this aggressive blood cancer.
Targeted drugs
An important question is really important growth factors which stage of development to lymphoma. Bergen: "It is likely that at the time of diagnosis already has decades of slumbering colitis patients. To what extent it helps to prevent the effect of the newly discovered growth factors with targeted drugs? Meanwhile, we have tested a large number of these substances in the laboratory and two seem promising. But that is therapeutically only interesting if these growth factors are also after the diagnosis still play a significant role. "
The findings of the Leiden and Amsterdam researchers published on January 3 in the journal Proceedings of the National Academy of Sciences of the USA (PNAS USA). The research was supported by a grant from Cancer Research Worldwide (WWCR).
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